SREBP, known as a central regulator of lipid metabolism and disease, has been identified as a key transcription factor in controlling both physiological and pathological lipid processes. The protein is synthesized as an inactive precursor before being cleaved to release active domains that enter the nucleus to promote gene transcription. While the classical activation pathway depends on SCAP in response to sterol depletion, endoplasmic reticulum stress can also activate SREBP independently.

Research conducted using keywords like 'SREBP' on various databases has shed light on the protein's role in different diseases and the potential of synthetic and natural compounds to inhibit its activity. These findings offer new perspectives on using SREBP as a therapeutic target for various illnesses.