Following a series of Israeli assaults on Tehran's nuclear program and armed forces, Iran has retaliated with missile and drone strikes on Israel, resulting in at least three deaths and dozens of injuries.

Israel's attack involved the use of planes and drones that were smuggled into the country in advance to target key facilities, kill senior generals, and scientists.

Iran's UN ambassador reported that 78 people were killed and over 320 were wounded in the retaliatory attacks.

Despite experts and the US government's assessment that Tehran was not actively pursuing a nuclear weapon, Israel claimed that the barrage was necessary to prevent Iran from getting closer to building one.

In response, Iran launched waves of drones and ballistic missiles at Israel, causing explosions that illuminated the skies over Jerusalem and Tel Aviv and shook the buildings below.

The Israeli military advised civilians, already affected by 20 months of conflict since Hamas's October 2023 attack, to seek shelter for several hours.

Israel's strikes have cast doubt on further talks between the US and Iran regarding a nuclear agreement, scheduled to take place in Oman on Sunday.

Iran's Supreme Leader, Ayatollah Ali Khamenei, condemned Israel's actions, vowing not to let them escape unpunished.

Iran launched missile attacks on Israel late on Friday, with state television broadcasting footage of the strikes, while Israel's military reported intercepting more drones near the Dead Sea.

In Tel Aviv, a hospital treated seven individuals injured in the second Iranian attack, with one fatality reported. Subsequently, another Iranian missile struck homes in Rishon Lezion, resulting in two deaths and 19 injuries.

Explosions and air defense systems firing at targets were heard in central Tehran shortly after midnight on Saturday.

Israel conducted overnight strikes on numerous targets, including air defenses in the vicinity of Tehran, according to the Israeli military.

Concerns about a full-scale war between the two nations have been raised, prompting global leaders to call for immediate de-escalation.

Iran's non-compliance with nuclear obligations led to condemnation by the UN's atomic watchdog, while the crossfire between Israel and Iran disrupted travel in the Middle East.

Key sites targeted by Israel included Iran's main nuclear enrichment facility in Natanz, a smaller facility in Fordo, and a research facility in Isfahan.

Israel also destroyed radar installations and missile launchers in western Iran, resulting in casualties among Iran's military leaders.

The attack, which had been planned for months, utilized explosive drones and precision weapons placed inside Iran by Israel's Mossad spy agency.