A recent study has demonstrated that transplanting healthy human glial progenitor cells into adult mice with Huntington’s disease can slow down the decline in motor and cognitive functions and increase their lifespan. These support cells were able to restore crucial neuronal functions, reverse synaptic damage, and reactivate gene expression even after symptoms had already appeared.

Shifting Therapeutic Approaches

Traditionally, Huntington’s disease has been viewed as a disorder primarily affecting neurons. However, recent research has highlighted the significant role of dysfunctional glial cells in the progression of the disease. These findings have opened up new possibilities for therapeutic interventions that focus on repairing the adult brain using glial-based treatments.

Key Findings:

• Glial Dysfunction: Glial cells play a crucial role in the development of Huntington’s disease.
• Restorative Effects: Transplanted glial cells improved motor skills, memory, and the structure of neurons.
• Adult Brain Repair: Positive outcomes were observed even when treatment was initiated after the onset of symptoms.