Iran's Supreme Leader Ayatollah Ali Khamenei rejected Donald Trump's demand for unconditional surrender on Wednesday, and the US president said his patience had run out, though he gave no clue as to what his next step would be.

Trump declined to reveal if he would join Israel's bombing campaign against Iran, stating that it was too late for discussions as Iranians fled from intensified Israeli airstrikes.

Israel announced the destruction of Iran's internal security service headquarters in the latest bombing, vowing to continue targeting symbols of governance and the Ayatollah regime.

In a televised speech, Khamenei warned the US against military intervention, emphasizing that the Iranian nation would not surrender despite threats.

Trump's statements have been inconsistent, ranging from diplomatic solutions to the possibility of US involvement in strikes against Iranian nuclear sites. Israel conducted airstrikes on Tehran, urging Iranians to evacuate certain areas for safety.